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KMID : 0356620150300010105
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Journal of Korean Society of Endocrinology
2015 Volume.30 No. 1 p.105 ~ p.109
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Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves’ Disease
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:Hwang In-Kyoung
:Kim Seon-Hye/:Lee Un-Joo/:Chin Sang-Ouk/:Rhee Sang-youl/:Oh Seung-Joon/:Woo Jeong-Taek/:Kim Sung-Woon/:Kim Young-Seol/:Chon Suk
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Abstract
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Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves’ disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves’ disease.
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KEYWORD
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HLA-DQ2, Celiac disease, Graves’ disease
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